HandBrake will scan the DVD ISO titles and load the contents. Click File (Open a single video file) on the left to import your ISO image file or you can drag and drop the ISO file directly to the interface. Run HandBrake and a Source Selection interface will pop up. Free Convert ISO to H.265 (x265) MP4 with Handbrake By converting ISO to HEVC/H.265, it greatly saves your hard drive space at a size of around 150MB. This means it offers better image quality in the same size or reduces video file size by half at the same level of video quality.
HEVC/H.265 doubles the data compression ratio at the same level of video quality compared with H.264. Follow the easy-peasy guide to convert ISO to HEVC/H265 codec with much size saved while keeping best quality!